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Sodium Lauryl Sulfate (SLS) Reduces Salivary and Plaque Fluoride Uptake
G.M. WHITFORD, H.T. AKINS, and S.M. ADAIR, Medical College of Georgia, Augusta, USA | Plaque fluoride
concentrations ([F]) are directly related to plaque calcium concentrations. Our
attempts to increase salivary and plaque F uptake from 1000-ppm dentifrices by
pre-rinsing with 20mM (Caries Res 39:100-107,2005) or 150mM (Eur J Oral Sci
114:489-493,2006) calcium solutions were unsuccessful. Ca pre-rinses, however,
caused large increases in F uptake from aqueous NaF rinses (Caries Res
40:449-454,2006; JDR 86, Sp Iss A:Abst 1873,2007). Objective: To test
the hypothesis that, when added to a rinse, SLS (anionic detergent in
dentifrices) reduces F uptake by saliva and plaque. Methods: Subjects
(n=11) rinsed with 20mL of 150mM Ca-lactate for 1.0 min, then with 20mL of
228-ppm F. Plaque was collected 15 and 60 min later; whole saliva was collected
60 min after the F rinse. After one week the procedure was repeated with 0.5%
SLS in the F rinse. F was analyzed with the electrode after five extractions
with pH-4.8 acetate-buffer (plaque) and after HMDS-facilitated diffusion
(plaque and saliva). The results were analyzed for statistically significant differences
using RM-ANOVA and Fisher's LSD post-hoc test. Results: Mean salivary
[F] (mean±SE) at 60 min after rinsing with or without SLS were 0.18±0.05 and
1.40±0.48 mmol/L (p=0.031). The plaque [F] are shown in the table (‘Without
SLS' vs ‘With SLS', p<0.01).
Amounts of F Extracted from Plaque (mmol/kg) | Extractor | Without SLS | With SLS | 15' | 60' | 15' | 60' | Acetate buffer | 43.06±6.92 | 30.88±3.08 | 23.32±4.85 | 19.52±2.29 | HMDS | 79.55±24.35 | 57.47±13.22 | 10.51±4.18 | 15.09±8.59 | Total | 122.61±30.00 | 88.35±13.50 | 33.83±6.39 | 34.61±9.17 |
Conclusion:
SLS (0.5%) in the F rinse significantly reduced salivary and plaque F uptake,
an effect presumably due to calcium binding by SLS. We suggest that dentifrices
formulated without SLS could have [F] substantially below 1000 ppm but have the
same cariostatic effect and reduce the risk of dental fluorosis.
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Seq #88 - Pharmacology, Therapeutics, & Toxicology 8:00 AM-9:30 AM, Friday, April 4, 2008 Hilton Anatole Hotel Metropolitan Ballroom |
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