Regenerative Periodontal Surgery with PRP and Anorganic Bovine Bone Mineral

Objective: To compare the healing of intrabony defects with a combination of Platelet Rich Plasma (PRP), (Curasan AG, Kleinostheim, Germany) + an anorganic bovine bone mineral (ABBM), (Bio-Oss®, Geistlich, Wolhusen, Switzerland) to ABBM alone. Methods: 30 (15/15) patients each of whom exhibited one deep intrabony defect were randomly treated with either PRP + ABBM or with ABBM . Probing pocket depth (PPD), gingival recession (GR) and clinical attachment level (CAL) were recorded at baseline and at 12 months. Results: No statistical significant differences in any of the investigated parameters between the two groups were observed at baseline. In the PRP + ABBM group mean PPD decreased from 8.6 ± 1.8 mm to 3.4 ± 1.4 mm (p<0.0001) and mean CAL changed from 10.2 ± 2.0 mm to 4.8 ± 1.9 mm (p<0.0001). In the ABBM group mean PPD decreased from 8.5 ± 2.0 mm to 3.1 ± 1.3 mm (p<0.0001) and mean CAL changed from 9.1 ± 2.7 mm to 4.0 ± 1.5 mm (p<0.0001). No statistically significant differences in terms of PPD reduction and CAL gain were found between the two groups. Conclusion: At one year after regenerative therapy of periodontal intrabony defects, optimal clinical results were obtained with anorganic bovine bone mineral (ABBM), with or without the addition of PRP.