SESSION Seq #91: Oral Pathogens Sequence Analysis and Comparative Study

Seq #91

Friday, April 4, 2008

9:45 AM-11:15 AM
Hilton Anatole Hotel Rosetta, Hands-on Workshop

Oral Pathogens Sequence Analysis and Comparative Study

Sponsored by: Microbiology / Immunology and Infection Control, NIDCR

Description: This tutorial will provide an introduction to genome level sequence analysis and an overview of the NIDCR-funded Oralgen database, as well as JGI/IMG and other commonly used bioinformatics tools. It will include a perspective on the many challenges remaining in the field and how some of them can be addressed with these tools and techniques. Examples to be presented include comparative analysis, illustrated by reductive pathway evolution and paralog emergence for new function. Subsystem annotation will be demonstrated by using metabolic reconstruction and identification of missing genes. The tutorial will provide the participants with adequate knowledge of the available tools, websites and databases to perform effective manual curation and comparative analysis. The format will be hands-on and the instructors are experienced sequence analysts from the Oralgen Database Team. Participants need a working knowledge at the advanced undergraduate level of microbiology, cell biology, biochemistry and molecular biology. Scientists who are NIDCR grant awardees are encouraged to attend, but the workshop is open to all. This program is financially supported by NIH-NIDCR.

Chairperson: G. XIE


0576	9:45 AM	Oralgen Database Introduction and Walk-thru T.S. BRETTIN, Los Alamos National Laboratory, NM, USA
	10:30 AM	Example of Comparative Analysis: Reductive Pathway Evolution, Paralog Emergence for New Function G. XIE, Los Alamos National Laboratory, CA, USA

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