Seq #141

Saturday, April 5, 2008

9:00 AM-10:30 AM
Hilton Anatole Hotel Grand Ballroom E, Symposium - Group/Division Sponsored

Mechanotransduction in Mineralized Tissues

Sponsored by: Implantology Research, Mineralized Tissue

Description: This symposium will address the fundamental mechanisms by which the formation and resorption of alveolar bone is affected by mechanical forces. Force transduction is of great importance in the oral cavity (e.g., occlusion) and is the basis of orthodontic tooth movement. Also, responses of alveolar bone cells to compression, extension and other forces plays an important role in the osseointegration of dental implants. Recent research has implicated the osteocyte as the key cell in the response to mechanical forces acting on the jaw. However, the mechanism by which the osteocyte senses and responds to forces is a critical missing piece of the puzzle. The proposed symposium will begin with an introduction by Dr. Lynda Bonewald of the University of Missouri Kansas City, a leading authority on osteocyte biology. Dr. Mitchell Schaffler of the Mount Sinai School of Medicine will then present an overview of mechanotransduction. By providing this background material, we hope to make the symposium useful for non-specialists such as trainees and junior investigators. Two talks will highlight the leading theories of mechanotransduction in mineralized tissues. Dr. Jean Jiang of the University of Texas will present his work on the role of gap junctions between osteocytes. Dr. Henry Donahue of Pennsylvania State University will present his work on the role of purine nucleotides in transduction. Finally, Dr. Clark Stanford of the University of Iowa will discuss the clinical aspects of mechanotransduction, particularly with respect to loading of dental implansts. Educational objectives: • To provide a comprehensive overview of current understanding of how mechanical forces affect the activities of cells in alveolar bone. • To reconcile proposed mechanisms of mechanotransduction involving gap junctions and purine nucleotides. • To initiate a dialog between basic scientists interested in cellular mechanisms of mechanotransduction and clinicians interested in occlusion, implant integration and orthodontia that will inform the former about clinical problems and the latter about potential solutions.

Chairperson: L.F. BONEWALD


0968	9:00 AM	Overview of Mechanotransduction in Mineralized Tissues M. SCHAFFLER, Mount Sinai School of Medicine, New York, NY, USA
	9:15 AM	a5 Integrin Association with Connexin 43 Regulates the Function of Osteocyte Hemichannels in Response to Fluid Flow Shear Stress J. JIANG, University of Texas - San Antonio / Health Science Ctr, USA
	9:30 AM	ATP and Bone Cell Mechanotransduction H. DONAHUE, Pennsylvania State University, Hershey, USA
	9:45 AM	Clincial Perspective of Mechanical Loading and Osseointegration C. STANFORD, University of Iowa, Iowa City, USA

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