MDM2 And P53 Expressions In Ameloblastoma And Keratocystic Odontogenic Tumor

Objectives:

 Ameloblastoma and keratocystic odontogenic tumor are characterized by a benign but locally invasive behavior with a high risk of recurrence.

MDM2, an amplifier of cell proliferation, and p53, a tumor suppressor protein, are over expressed in some odontogenic lesions.

 This study was designed to assess the relationship between expression of MDM2 and P53 and proliferative activity and local invasion of these two entities.

Methods:

 The expression of MDM2 and P53 proteins were determined immunohistochemically in paraffin sections of 39 ameloblastomas (15 follicular ,15 plexiform and 9 unicystic types) and 15keratocystic odontogenic tumors.

Statistical analysises were performed using One way ANOVA, T-Test, Kruskal-Wallis, Mann-Whiteny U and Kendall testes.

Results:

 P53 protein was expressed in 100% of keratocystic odontogenic tumors and 79.6%of ameloblastomas and MDM2 was detected in79.48% of ameloblastomas and 80% of keratocystic odontogenic tumors.

 There were no statistical differences between MDM2 and P53 expression in different subtypes of ameloblastomas and keratocystic odontogenic tumors compared with them. (P>0.05)

Grade and severity of MDM2 and P53 expression were similar in subtypes of ameloblastomas and keratocystic odontogenic tumors. (P>0.05)

But there was significant difference between grades and severity of MDM2 expression in the subtypes of ameloblastomas. (P<0.05)

There was a positive correlation between MDM2 and P53 expression.

Conclusion:

 Since over expression of P53 and MDM2 is associated with proliferative activity of ameloblastomas and keratocystic odontogenic tumors, we realized that these lesions have same biological behavior, in term of local invasion and high recurrence rate.