Drug therapy of psychotic disorders in oral lichen planus

Objective:

 Current treatments of oral lichen planus are palliative, not curative. Because of the importance of psychological disorders in the development and severity of oral lichen planus, the use of psychotic therapy may be an adjunct treatment in curing the lesions.

        The purpose of this study was to determine the efficacy of drug therapy of psychotic disorders in oral lichen planus.

      Methods:

Fifty-four patients with oral lichen planus and psychotic disorders were enrolled in our controlled clinical study and were randomly divided into two groups. Both groups were given topical corticosteroids and the case group received additional psychotic drug therapy. Patients were followed for at least 2 months. Response to treatment was evaluated in each group and was compared with the other group by Wilcoxon and Mann-Whitney tests. 

       Results:

 Decrease in the size of the lesions was significantly greater in the case group after six months, but this difference was not significant in relation to burning sensation and form of the lesions. In the case group, size of the lesions decreased after 2, 4 and 6 months and form of the lesions and burning sensation revealed a significant decrease after 2 and 6 months.

Conclusion:

 Combination of psychotic therapy and routine treatment modalities may be a valuable therapeutic tool for oral lichen planus.

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