The Effects of Peptide-coated Surface on Osseointegration of Titanium Implants

Objective: The aim of the present study was to evaluate the effect of peptide(including fibrin binding site of Fibronectin) coated titanium implant on the osseointegration in rabbit tibia by removal torque test and histomorphometric analysis.

Methods: The threaded implants were manufactured by Warantec Co. Ltd. The length was 6.0 mm, the outer diameter was 3.75 mm and the pitch height was 0.6 mm. Synthetic oligopeptide including fibronectin(FN) based fibrin binding sequence was gained from NH2 terminal of FN. In the current experiment, the devices were designed with two different surface characteristics : (1) control group : rough surface(Advanced Blasting and Etching) (2) test group : rough surface(ABE) with synthetic oligopeptide coating. Four mature New Zealand white rabbits were used for the experiments. On the right leg of rabbit, two implants without coating were installed, and on the left leg, two implants with synthetic oligopeptide coating were installed. The proximal one of two implants was for the histomorphometric analysis, and the distal one was for evaluation of the removal torque value in each leg.

Results: The RTVs(removal torque value) of test group had a tendency to be higher than that of control group. The difference between test and control of 2-week healing was largest. In the case of 4, 8, 12-week healing, the difference was small.The BIC of peptide-coated implants had a tendency to be higher than that of control group. The difference between test and control of 2-week healing was largest. In the case of 4, 8, 12-week healing, both groups showed similar trend.

Conclusion: Synthetic oligopeptide coated surface implants showed higher RTV and BIC in the early stage of healing than uncoated ones