Remineralization of Artificial Caries by CPP-ACP Paste

Objectives: This study evaluated the effectiveness of casein phosphopeptide-amorphous calcium phosphate paste (CPP-ACP paste) on remineralization in smooth surface artificial caries of both permanent and deciduous teeth after 3-minute CPP-ACP paste application. Methods: Forthy human teeth 20 extracted premolar and 20 exfoliated primary molars with sound buccal surfaces underwent soft tissue debridement , then bucco-lingual longitudinally sectioned into two parts. In addition, an acid resistant varnish was coated on enamel surface leaving buccal window exposed. Following artificial caries creation, each specimen was randomly divided into experiment and control groups of permanent as well as deciduous teeth, respectively. Only experiment groups were applied with CPP-ACP paste (Tooth Mousse, GC Corp.,Japan) for 3 minutes, twice a day. Finally all of the specimens were treated in pH-cycled for 4 weeks. Consequently, the thin section was performed and evaluated lesion area under polarized light microscope. Results: The paired-t test was selected to compare lesion area difference between pre- and post-treatment in both experiment and control groups. It demonstrated significantly lesion area reduction (P<0.00) in experiment groups. (both permanent and deciduous teeth) Conclusion: According to these results CPP-ACP paste is effective on remineralization of artificial caries on smooth surface of human tooth (both permanent and deciduous teeth)

This research was supported by Graduate School Chulalongkorn University, Bangkok Thailand