Effects of 0.454% SnF2 Dentifrice on Daytime and Overnight Malodor

Objective: A clinical study was conducted to evaluate day time and overnight oral malodor reduction benefit of a 0.454% SnF2 therapeutic dentifrice with short-term and long-term use. Methods: The study was a randomized, double-blinded, two-treatment, 3-period cross-over clinical trial. After completing an acclimation period, 45 subjects with existing oral malodor were randomly assigned to a cross-over treatment sequence consisting of 0.454% SnF2 Crest® Pro-Health™ dentifrice (SnF2 dentifrice) and Crest® Cavity Protection dentifrice (control). For each treatment period, subjects brushed with the assigned product twice a day for 7 days. Oral malodor was assessed on a 9-point hedonic scale at Baseline, Day 2 - overnight, Day 2 – daytime (4 hours post morning brushing), Day 8 - overnight, Day 8 - daytime (4 hours post morning brushing). Treatment periods were separated by wash-out periods during which subjects brushed with the control dentifrice. Results: Subjects had a mean age of 39 years, 58% of the subjects were female and the mean Baseline hedonic score was 7.4. Relative to the control, use of the SnF2 dentifrice resulted in significant (p < 0.002) improvement of the overnight and daytime malodor both short-term at Day 2 and long-term at Day 8. The mean overnight hedonic scores were 3.2 and 5.1 at Day 8 after 1 week of brushing for the SnF2 and the control dentifrice, respectively. The mean daytime hedonic scores were 2.4 and 4.1 at Day 8 for the SnF2 and the control dentifrice, respectively. Conclusion: The use of the 0.454% SnF2 dentifrice resulted in significant reduction in short-term and long-term daytime and overnight malodor relative to a control dentifrice.