Oral Malodor Reduction with 3-week Use of 0.454% SnF2 Dentifrice

Objective: This clinical study evaluated the effects of the 3-week use of a 0.454% SnF2 therapeutic dentifrice on oral malodor. Methods: The study was a randomized, double-blinded, two-treatment, parallel design clinical trial. After completing an acclimation period, 71 subjects with existing oral malodor were randomized to one of the two treatments: 0.454% SnF2 Crest® Pro-Health™ dentifrice (SnF2 dentifrice) or Crest® Cavity Protection dentifrice (control). Subjects brushed with the assigned product twice a day for 3 weeks. Oral malodor was assessed on a 9-point hedonic scale at Baseline, Week 1 and Week 3. Results: The mean age of study participants was 37.8 and 59% were female. The baseline mean hedonic score was 8.19. At Week 1, the mean hedonic scores (SE) were 3.40 (0.18) and 6.62 (0.18) for the SnF2 dentifrice and the control dentifrice, respectively. At Week 3, the mean hedonic scores (SE) were 1.55 (0.18) and 5.28 (0.18) for the SnF2 dentifrice and the control dentifrice, respectively. Relative to the control, the use of the SnF2 dentifrice resulted in significantly (p < 0.0001) greater reduction in oral malodor at both visits. Both treatments were well-tolerated. Conclusion: Three-week use of the 0.454% SnF2 dentifrice resulted in sustained significant improvement in oral malodor relative to a control dentifrice.