RCT Comparing Natural Tooth Stain Removal of Two Whitening Dentifrices

Objectives: A randomized controlled clinical trial was conducted to evaluate the clinical effectiveness of two whitening dentifrices on natural tooth stain removal. Methods: 30 generally healthy adults with visible extrinsic facial stain on 6 anterior teeth were randomly assigned to a standard manual toothbrush and one of two whitening dentifrices. Subjects received either an experimental anti-cavity whitening dentifrice or a marketed control (Crest® Vivid White™) for unsupervised twice daily brushing. Stain area and intensity were measured using a standard index (Lobene) at baseline and after 14 days treatment. Results: Mean (SD) age was 45.4 (13.0) years, with females comprising 67% of the study population. One subject in the control was lost to follow-up. All other subjects completed the 14-day study and were included in the analysis. The population presented with appreciable stain at baseline, with composite stain mean (SD) of 2.27 (0.37) and 2.35 (0.82) in the experimental and control groups respectively. Groups were balanced on pertinent demographic and behavioral parameters and baseline stain (p>0.43). Both groups exhibited significant (p < 0.0001) stain reduction relative to baseline at day 14. At the end of treatment, median composite stain removed was 84% in the experimental group and 83% in the control group. Groups did not differ significantly (p = 0.69) on day 14 composite stain. Both dentifrices were well-tolerated, with only 1 report of oral irritation during treatment. Conclusion: In a randomized controlled clinical trial, 14 days use of an experimental anti-cavity whitening dentifrice removed appreciable natural extrinsic tooth stain.