Fluoride Release of a Nanoparticulated Resin-Modified Glass Ionomer Cement

Short-term fluoride releases from glass ionomer cements (GICs) are related to their matrices, fillers, setting mechanisms and fluoride content. There is a new GIC in the market with nanoparticulated fillers which could influence the fluoride release.

Objectives: The purpose of this study was to compare the fluoride release profile of a new nanoparticulated resin-modified GIC (KN-Ketac N100®) with resin-modified GIC (V-Vitremer®), high viscosity GIC (KM-Ketac Molar Easymix®) and nanoparticulated composite resins (control-Filtek Z350®).

Methods: The materials were prepared according to the manufacturers' directions. Disc specimens (n=6, each material) were placed into 4ml of deionized water in sealed polyethylene vials and shaked at 1.4 Hz at 37°C. Fluoride release was measured daily using a fluoride-ion specific electrode up to 15 days.Data were tested by ANOVA and Tukey's test (p<0.05).

Results: ANOVA and Tukey's test showed higher fluoride release at the first day for resin-modified GIC (V) followed by high viscosity GIC (KM), nanoparticulated resin-modified GIC (KN) and composite resin (control), which significantly differed from each other (p<0.05). The composite resin (control) showed the shortest fluoride release. Release rates of the GIC (V) and GIC (KN) on the 2nd until the 6th days were significantly higher than the GIC (KM). After that day, there were no significant differences among the GICs.

Conclusions: The new nanoparticulated resin-modified GIC (KN) did not show the highest fluoride release at the first day. However at the 2nd until the 6th days this material and the resin-modified GIC (V) were the most effective materials with regard to fluoride release. After this period the fluoride release was similar for all the studied GICs until the 15th day.