Comparison of Two Systemically- administered Ibuprofen Dosages in Gingivitis Treatment

Objectives: Non-steroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen have now been widely researched in an attempt to modify the host-response in periodontal disease. Ibuprofen inhibits synthesis of prostaglandin E2. Prostaglandin E2 (PGE2) is an important stimulator of bone resorption and a potential mediator in the etiology of periodontal disease.

The purpose of this study is to compare two different systemic Ibuprofen dosages administered as an adjunct to scaling in reduction of gingival index, bleeding index and plaque index in gingivitis.

Methods: 30 patients with moderate or sever gingivitis were selected and randomly divided into three groups:

First group (control): received scaling and oral hygiene instruction.

Second group (case 1): received scaling and oral hygiene instruction plus daily Ibuprofen 200 m for a week.

Third group (case 2): received scaling and oral hygiene instruction plus daily Ibuprofen 400mg for a week.

In all groups at baseline (day 0), days 7 and 14, Oxlery plaque index, Bleeding Point index and Loe & Silness gingival index, were assessed. Then the results were compared in each group and between the three groups.

Results: In all the three groups plaque index, bleeding index and gingival index reduced and the differences between 0, 7and 14 day of study were statistically significant (pv<0.05).Comparison of the indices between three groups showed that there were more reduction of PLI, BI and GI in second and third groups. However there were no statistically significant difference between these two groups (pv>0.05).

Conclusion: it was suggested that the bleeding and inflammatory status of the gingiva can be reduced by using the systemic Ibuprofen in conjunction to scaling and administration of the lower dose is as much useful.

Key words: gingivitis, Ibuprofen, scaling, plaque index, bleeding index and gingival index.