SESSION Seq #0: Pyrophosphate and SIBLING Proteins Regulating Mineralization

Thursday, July 3, 2008

12:15 PM-1:30 PM
Metro Toronto Convention Centre Level 600 Foyer (Reg Area), Lunch and Learning

Pyrophosphate and SIBLING Proteins Regulating Mineralization

Sponsored by: Mineralized Tissue

Description: Molecular determinants of skeletal, dental and pathologic mineralization include inhibitory SIBLING proteins, and the small-molecule inhibitor pyrophosphate. These mineralization inhibitors are substrates for tissue-nonspecific alkaline phosphatase, an enzyme that degrades pyrophosphate and dephosphorylates SIBLING proteins, thus modifying their mineral-inhibiting activity. The influence of these factors on mineralization will be discussed.


			Pyrophosphate and SIBLING Protiens Regulating Mineralization M.D. MCKEE, McGill University, Montreal, Canada

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