| Thursday, July 3, 2008 | ||||||||
| 12:15 PM-1:30 PM Metro Toronto Convention Centre Level 600 Foyer (Reg Area), Lunch and Learning | ||||||||
| Antiseptic Rinses for the Control of Subgingival Biofilm. Is there Evidence? | ||||||||
Sponsored by: Periodontal Research | ||||||||
| Description: The aim of this presentation is to give an overview on the evidence of antiseptics and local antibiotics for the control of subgingival biofilm. Since there is evidence for the infectious aetiology of periodontitis, major research efforts have tried to assess the possibility of using antimicrobials against putative pathogens in subingival biofilm. In order to be effective in vivo an efficacious pharmacological agent must reach its site of action, must be maintained there at an adequate concentration and it must remain long enough to the intended pharmacological effect to occur. The first problem is due to the fact that an intracrevicularly placed antimicrobial will be cleared from the periodontal pocket by the outward flow of an inflammatory exudate (i.e. the crevicular fluid). The second problem is that an antimicrobial action on biofilm bacteria requires concentrations of the active agent that are several orders of magnitude greater than those effective on planctonic bacteria. Although subgingival rinses/irrigations can generally reach the apical parts of the pocket, they do not achieve the required duration at the base of the pocket to ensure an optimal effect. An alternative to ensure for better control of the concentration and time principles is the use of local delivery devices. Different delivery systems will be discussed. | ||||||||
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