SESSION Seq #48: Osteoimmunology and Host Defense in the Periodontium

Seq #48

Thursday, July 3, 2008

10:45 AM-12:15 PM
Metro Toronto Convention Centre Room 718B, Symposium - Group/Division Sponsored

Osteoimmunology and Host Defense in the Periodontium

Sponsored by: Microbiology / Immunology and Infection Control, Periodontal Research

Description: Recent evidence supports the emerging paradigm that host immunity against periodontal biofilm is critical to the regulation of alveolar bone integrity, called “osteoimmunology”. The symposium will describe the basic concepts, mechanisms and the latest advances in this field related to our periodontal host defense system, its pathogenesis and potential treatment. The scope of this osteoimmunology symposium is to introduce the fundamental concepts and recent advances regarding the implications of periodontal immunity, and its mechanisms for regulating alveolar bone loss (i.e., osteoclastogenesis) during periodontal pathogenesis and host defense. The presentations are aiming to: i) induce the basic concepts of osteoimmunology and its relationship to periodontal pathogenesis to dental teachers/educators, students and researchers; ii) critically evaluate the relevance of this new field in periodontal disease and its biological significance; iii) stimulate discussion and mutual understanding among dental educators, students and researchers and its importance to the aspects of periodontal health vs. disease; iv) facilitate the development of new approaches for future treatment of inflammatory human periodontal disease. The symposium goals include: i) the emerging concepts of osteoimmunology and its signaling interactions associated with periodontal host defense and pathogenesis; ii) the molecular mechanisms of osteoimmunology in regulating periodontal bone loss; iii) the gene-transfer approach for delivering critical osteo-immune molecules to the periodontium; iv) the new link between the innate immunity and osteoimmunology regarding inflammation-induced bone loss in the inflammatory bone disorders. The topics to be covered are: i) general principle/phenomenon of the cross-talk between immune system and bone-skeletal cells; ii) emerging and critical role of osteoimmunology in the periodontal host defense and disease; iii) molecular mechanisms of osteoimmunology in periodontal bone loss; iv) local gene transfer of osteo-immune molecules to the periodontium as the potential therapy; and v) new links between dendritic cells-associated innate immunity and osteoimmunology during inflammation-induced bone loss.

Chairperson: Y.-T.A. TENG


	0208		Regulation of Immune Receptors and Signaling in Osteoclasts by Oseotropic Cytokines and Steroid Hormones U.H. LERNER, Umeå University, Sweden
			Osteimmunology of Periodontitis: Interference with Immune Mechanisms of Bone Resportion M. TAUBMAN, Forsyth Institute, Boston, MA, USA
			Novel Periodontal Therapy Using Local Gene Transfer H. KANZAKI, Tohoku University, Sendai, Japan
			Linking Periodontal Innate vs. Adaptive Immunity to Inflammation-induced Bone Loss: A New Paradigm? Y.-T.A. TENG, University of Rochester, NY, USA
			Discussion

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