| Seq #136 | Friday, July 4, 2008 | |||||||
| 8:00 AM-8:45 AM Metro Toronto Convention Centre Room 808, Plenary | ||||||||
| The Unholy Trinity of Infectious Diseases: Role of the Pathogen, Host, and Microbiota | ||||||||
Sponsored by: Plenary | ||||||||
| Description: Pathogenic E. coli cause much morbidity and mortality worldwide. Two types of E. coli (enteropathogenic E. coli [EPEC] and enterohemorrhagic E. coli [EHEC, or O157]) cause severe diarrhea, with EHEC also causing hemolytic uremic syndrome in a subset of cases. These pathogens subvert host epithelial cells, exploiting cytoskeletal processes to build a cellular protrusion (pedestal) on the cell surface, and subverting various innate immune pathways. The host response also plays a critical role in disease development, and we have been exploiting a murine infection model to study host contribution to disease. Finally, we have begun to examine the impact of diarrheal disease and inflammation on the normal microbiota during infection. Collectively, these three components contribute to disease, and only by studying all three does one fully understand the molecular complexity of bacterial disease. | ||||||||
| ||||||||
| Back to the: Plenary Session Program | ||||||||
©Copyright 2008 American Association for Dental Research. All Rights Reserved.