Evaluation of Adenoid cystic and polymorphous low-grade adenocarcinoma by immunohistochemistry

Objectives:

This study use of  immunohistochemical markers for distinguishing between PLGA and AdCC who have several overlapping histological and clinical features .

Methods:

Ten AdCC and eight  PLGA with five  normal minor salivary glands  were selected after  review by two oral pathologists .  LSAB method for seven markers:

Carcinoembryonic antigen , Epithelial membrane antigen , muscle specific actin , Vimentin, S100, P53 and Ki-67.

Finally, our data was qualitated by Mann Whiteny test.

Results:

Analysis of data show a high expression of CEA, EMA and Ki-67 in AdCC compared to PLGA. Although, CEA (P=0.006) expression was limited to luminal cells .In contrast, MSA (P=0.011) expression in nonluminal cells, and Ki-67 (P<0.001) occurred in both luminal and nonluminal cells.

Conclusion:

The result of this study suggests that ICH can be a helpful tool.The immunostaining of AdCC and PLGA with CEA, Vimentin and Ki-67 were of greater  significant, S100 and MSA was less significant and the others (EMA and P53) could not offer an adjunctive aid in differential diagnosis between two tumors